Botulinum Toxin on Frey Syndrome: Who to Treat? Case Report and Literature Review

Auteurs

  • José Bissaia Barreto Serviço de Medicina Física e de Reabilitação, Centro Hospitalar de Entre Douro e Vouga, Santa Maria da Feira, Portugal
  • Joana Matos Serviço de Medicina Física e de Reabilitação, Centro Hospitalar de Entre Douro e Vouga, Santa Maria da Feira, Portugal
  • Sónia Tomé Serviço de Medicina Física e de Reabilitação, Centro Hospitalar de Entre Douro e Vouga, Santa Maria da Feira, Portugal
  • Vítor Costa Pereira Serviço de Medicina Física e de Reabilitação, Centro Hospitalar de Entre Douro e Vouga, Santa Maria da Feira, Portugal
  • Inês Táboas Serviço de Medicina Física e de Reabilitação, Centro Hospitalar de Entre Douro e Vouga, Santa Maria da Feira, Portugal
  • Sofia Toste Serviço de Medicina Física e de Reabilitação, Centro Hospitalar de Entre Douro e Vouga, Santa Maria da Feira, Portugal
  • Catarina Aguiar Branco Serviço de Medicina Física e de Reabilitação, Centro Hospitalar de Entre Douro e Vouga, Santa Maria da Feira, Portugal

DOI :

https://doi.org/10.25759/spmfr.385

Mots-clés :

Botulinum Toxins, Type A/therapeutic use, Sweating, Gustatory/drug therapy

Résumé

Frey syndrome is mostly seen after parotidectomies and is an underdiagnosed surgical complication that may cause social inhibition and quality of life (QoL) deterioration. We report a case complemented with a literature review regarding the use of botulinum toxin on Frey syndrome. We consulted the patient’s file and photographed the Minor tests. We searched PubMed using the keywords: Frey syndrome; gustatory sweating; botulinum toxin. A 43-year-old woman, diagnosed with a pleomorphic adenoma of the left parotid gland treated by parotidectomy was referred to our Physical and Rehabilitation Medicine department due to symptoms suggestive of Frey syndrome: flushing and sweating on the left parotid region during meals with impact on socialization and QoL. Minor test confirmed the diagnosis. The patient underwent intradermic infiltration of 46U of onabotulinum toxin A (Botox®) across the positive area on Minor test that matched the patient’s complaints. Three weeks post-procedure, the patient denied hyperhidrosis (demonstrated on Minor test) and mentioned overall improvement on QoL. Treatment is symptomatic and should be offered to those patients whose symptoms cause a negative impact on QoL. Botulinum toxin infiltration is currently the gold standard treatment, since it is a safe, effective and reliable procedure. The Minor test is essential to optimise botulinum toxin dosage, thus reducing the possibility of occurring adverse effects.

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Références

Lopes T, Barroso L, Mesquita M, Bitoque S, Lopez D, Ferreira A. Síndrome de Frey – Uma visão global do tema. Rev Port Estomatol Med Dent Cir Maxilofac. 2013; 54: 103-114. Portuguese. doi: 6210.1016/j.rpemd.2016. 02.002

Motz KM, Kim JY. Auriculotemporal Syndrome (Frey Syndrome). Otolaryngol Clin North Am. 2016 49: 501-9. doi: 10.1016/j.otc.2015.10.010.

Steffen A, Rotter N, König IR, Wollenberg B. Botulinum toxin for Frey’s syndrome: a closer look at different treatment responses. J Laryngol Otol. 2012; 126: 185-9. doi: 10.1017/S0022215111002581.

Gualberto GV, Sampaio FM, Madureira NA. Use of Botulinum toxin type A in Frey´s syndrome. An Bras Dermatol. 2017;92:891-2

Jansen S, Jerowski M, Ludwig L, Fischer-Krall E, Beutner D, Grosheva M. Botulinum toxin therapy in Frey’s syndrome: a retrospective study of 440 treatments in 100 patients. Clin Otolaryngol. 201;42:295-300. doi: 10.1111/coa.12719.

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Publiée

2021-01-14

Comment citer

1.
Bissaia Barreto J, Matos J, Tomé S, Costa Pereira V, Táboas I, Toste S, et al. Botulinum Toxin on Frey Syndrome: Who to Treat? Case Report and Literature Review. SPMFR [Internet]. 14 janv. 2021 [cité 30 oct. 2024];32(4):174-8. Disponible sur: https://spmfrjournal.org/index.php/spmfr/article/view/385

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