Intra-Articular Botulinum Toxin in Osteoarthritis Treatment: A Systematic Review
DOI :
https://doi.org/10.25759/spmfr.510Mots-clés :
Botulinum Toxins/therapeutic use, Botulinum Toxins, Type A/therapeutic use, Injections, Intra-Articular, Osteoarthritis/drug therapyRésumé
Introduction: The study aimed to analyze current evidence regarding the effects of intra-articular (IA) Botulinum Toxin (BoNT) application in Osteoarthritis (OA) treatment on pain management and functional improvement.Methods: A comprehensive search of PubMed, Cochrane Central Register of Controlled Trials (CENTRAL) and Scopus databases from inception until October 2023 was performed according to PRISMA guidelines. The keywords were: “Injections, Intra-articular” AND “Botulinum toxins” AND “Osteoarthritis”. The inclusion criteria were: i) studies made with human study groups; ii) studies made in people with a diagnosis of osteoarthritis of any joint; iii) studies that used botulinum toxin type A; iv) studies that applied intra-articular BoNT in a joint. The exclusion criteria were: i) review articles; ii) follow-up periods with less than a month. Two independent reviewers were responsible for the selection and data extraction from each study.
Results: Three hundred and twenty-eight studies were reviewed and nineteen articles met the inclusion criteria. The studies compared IA BoNT to placebo and other OA treatments in temporomandibular, shoulder, knee and ankle joints.
Conclusion: Results reveal that IA BoNT can have short and long-term clinical benefits in pain control and mobility in patients with OA. However, more Randomized Clinical Trials (RCTs) should be performed to determine the effective dosages to administer IA BoNT for each joint.
Téléchargements
Références
Neogi T. The epidemiology and impact of pain in osteoarthritis. Osteoarthritis Cartilage. 2013;21(9):1145-1153. doi:10.1016/j.joca.2013.03.018
Nelson AE. Osteoarthritis year in review 2017: clinical. Osteoarthritis Cartilage. 2018;26(3):319-325. doi:10.1016/j.joca.2017.11.014
Dantas LO, Salvini T de F, McAlindon TE. Knee osteoarthritis: key treatments and implications for physical therapy. Braz J Phys Ther. 2021;25(2):135-146. doi:10.1016/j.bjpt.2020.08.004
Abramoff B, Caldera FE. Osteoarthritis: Pathology, Diagnosis, and Treatment Options. Medical Clinics of North America. 2020;104(2):293-311. doi:10.1016/j.mcna.2019.10.007
Palazzo C, Nguyen C, Lefevre-Colau MM, Rannou F, Poiraudeau S. Risk factors and burden of osteoarthritis. Ann Phys Rehabil Med. 2016;59(3):134-138. doi:10.1016/j.rehab.2016.01.006
Sconza C, Leonardi G, Carfì C, et al. Intra-Articular Injection of Botulinum Toxin for the Treatment of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials. Int J Mol Sci. 2023;24(2). doi:10.3390/ijms24021486
Arendt-Nielsen L, Jiang GL, DeGryse R, Turkel CC. Intra-articular onabotulinumtoxinA in osteoarthritis knee pain: effect on human mechanistic pain biomarkers and clinical pain. Scand J Rheumatol. 2017;46(4):303-316. doi:10.1080/03009742.2016.1203988
Mendes JG, Natour J, Nunes-Tamashiro JC, Toffolo SR, Rosenfeld A, Furtado RNV. Comparison between intra-articular Botulinum toxin type A, corticosteroid, and saline in knee osteoarthritis: a randomized controlled trial. Clin Rehabil. 2019;33(6):1015-1026. doi:10.1177/0269215519827996
Boon AJ, Smith J, Dahm DL, et al. Efficacy of Intra-Articular Botulinum Toxin Type A in Painful Knee Osteoarthritis: A Pilot Study. PM and R. 2010;2(4):268-276. doi:10.1016/j.pmrj.2010.02.011
Chou CL, Lee SH, Lu SY, Tsai KL, Ho CY, Lai HC. Therapeutic effects of intra-articular botulinum neurotoxin in advanced knee osteoarthritis. Journal of the Chinese Medical Association. 2010;73(11):573-580. doi:10.1016/S1726-4901(10)70126-X
Hsieh LF, Wu CW, Chou CC, et al. Effects of Botulinum Toxin Landmark-Guided Intra-articular Injection in Subjects With Knee Osteoarthritis. PM and R. 2016;8(12):1127-1135. doi:10.1016/j.pmrj.2016.05.009
Bao X, Tan JW, Flyzik M, Ma XC, Liu H, Liu HY. Effect of therapeutic exercise on knee osteoarthritis after intraarticular injection of botulinum toxin type a, hyaluronate or saline: A randomized controlled trial. J Rehabil Med. 2018;50(6):534-541. doi:10.2340/16501977-2340
McAlindon TE, Schmidt U, Bugarin D, et al. Efficacy and safety of single-dose onabotulinumtoxinA in the treatment of symptoms of osteoarthritis of the knee: results of a placebo-controlled, double-blind study. Osteoarthritis Cartilage. 2018;26(10):1291-1299. doi:10.1016/j.joca.2018.05.001
Singh JA, Mahowald ML, Noorbaloochi S. Intraarticular botulinum toxin A for refractory painful total knee arthroplasty: A randomized controlled trial. Journal of Rheumatology. 2010;37(11):2377-2386. doi:10.3899/jrheum.100336
Rezasoltani Z, Dadarkhah A, Tabatabaee SM, Mofrad MK, Mofrad RK, Abdorrazaghi F. Therapeutic effects of intra-articular botulinum neurotoxin versus physical therapy in knee osteoarthritis. Anesth Pain Med. 2021;11(3). doi:10.5812/aapm.112789
Singh JA, Mahowald ML, Noorbaloochi S. Intra-articular botulinum toxin A for refractory shoulder pain: a randomized, double-blinded, placebo-controlled trial. Translational Research. 2009;153(5):205-216. doi:10.1016/j.trsl.2009.02.004
Hashemi SM, Mehdi S, Khamene H, Naderi-Nabi B, Ghasemi M. Effects of Ultrasound-Guided Intraarticular Botox vs. Corticosteroids for Shoulder Osteoarthritis. Vol 22. www.apicareonline.com
Sun SF, Hsu CW, Lin HS, Chou YJ, Chen JY, Wang JL. Efficacy of Intraarticular Botulinum Toxin A and Intraarticular Hyaluronate plus Rehabilitation Exercise in Patients with Unilateral Ankle Osteoarthritis: A Randomized Controlled Trial.; 2014. http://www.jfootankleres.com/content/7/1/9
Najafi S, Sanati E, Khademi M, Abdorrazaghi F, Mofrad RK, Rezasoltani Z. Intra-articular botulinum toxin type A for treatment of knee osteoarthritis: Clinical trial. Toxicon. 2019;165:69-77. doi:10.1016/j.toxicon.2019.04.003
Mahowald, M. L., Singh, J. A., & Dykstra, D. D. (2006). Long term effects of intra-articular botulinum toxin a for refractory joint pain. Neurotoxicity Research, 9(2-3), 179-188. https://doi.org/10.1007/BF03033937
Sari BC, Develi T. The effect of intraarticular botulinum toxin-A injection on symptoms of temporomandibular joint disorder. Journal of Stomatology, Oral and Maxillofacial Surgery. 2022 Oct;123(5):e316-e320. DOI: 10.1016/j.jormas.2022.04.019.
Batifol D, Huart A, Finiels PJ, Nagot N, Jammet P. Effect of intra-articular Botulinum toxin injections on temporo-mandibular joint pain. J Stomatol Oral Maxillofac Surg. 2018;119(4):319-324. doi:10.1016/j.jormas.2018.06.002
Ko GD, Lam KI, Looi J, Koprowicz KT, Tsai M, Hein TR. Beyond the muscular effects – OnabotulinumtoxinA injections for pain control in chronic knee osteoarthritis: A case report. J Pain Res. 2018;11:1967-1970. doi:10.2147/JPR.S159841
Singh JA, Mahowald ML, Kushnaryov A, Goelz E, Dykstra D. Repeat injections of intra-articular botulinum toxin a for the treatment of chronic arthritis joint pain. Journal of Clinical Rheumatology. 2009;15(1):35-38. doi:10.1097/RHU.0b013e3181953b14
Fenollosa Vázquez P, Aguirre RMI, Canós Verdecho MA, Delgado JP. Efectos de La Toxina Botulínica A (Botox ® ) Intraarticular En La Artrosis de Rodilla Avanzada.; 2011.
Goldring MB, Otero M. Inflammation in osteoarthritis. Curr Opin Rheumatol. 2011;23(5):471-478. doi:10.1097/BOR.0b013e328349c2b1
Syx D, Tran PB, Miller RE, Malfait AM. Peripheral Mechanisms Contributing to Osteoarthritis Pain. Curr Rheumatol Rep. 2018;20(2). doi:10.1007/s11926-018-0716-6
Hassan H, Walsh DA. Central pain processing in osteoarthritis: implications for treatment. Pain Manag. 2014;4(1):45-56. doi:10.2217/pmt.13.64
Schaible HG, Schmelz M, Tegeder I. Pathophysiology and treatment of pain in joint disease. Adv Drug Deliv Rev. 2006;58(2):323-342. doi:10.1016/j.addr.2006.01.011
Arezzo, Joseph C. PH.D.. Possible Mechanisms for the Effects of Botulinum Toxin on Pain. The Clinical Journal of Pain 18(6):p S125-S132, November 2002
Téléchargements
Publiée
Comment citer
Numéro
Rubrique
Licence
© Revista da Sociedade Portuguesa de Medicina Física e de Reabilitação 2024
Ce travail est disponible sous licence Creative Commons Attribution - Pas d'Utilisation Commerciale - Pas de Modification 4.0 International.
Os manuscritos devem ser acompanhados de declaração de originalidade, Autoria e de cedência dos direitos de propriedade do artigo, assinada por todos os Autores.
Quando o artigo é aceite para publicação é obrigatória a submissão de um documento digitalizado, assinado por todos os Autores, com a partilha dos direitos de Autor entre Autores e a Revista SPMFR, conforme minuta:
Declaração Copyright
Ao Editor-chefe da Revista da Sociedade Portuguesa de Medicina Física e Reabilitação
O(s) Autor(es) certifica(m) que o manuscrito intitulado:
____________________________________________________________________ (ref.Revista da SPMFR_________) é original, que todas as afirmações apresentadas como factos são baseados na investigação do(s) Autor(es), que o manuscrito, quer em parte quer no todo, não infringe nenhum copyright e não viola nenhum direito da privacidade, que não foi publicado em parte ou no todo e que não foi submetido para publicação, no todo ou em parte, noutra revista, e que os Autores têm o direito ao copyright.
Todos os Autores declaram ainda que participaram no trabalho, se responsabilizam por ele e que não existe, da parte de qualquer dos Autores conflito de interesses nas afirmações proferidas no trabalho.
Os Autores, ao submeterem o trabalho para publicação, partilham com a Revista da SPMFR todos os direitos a interesses do copyright do artigo.
Todos os Autores devem assinar
Data:
Nome(maiúsculas)
Assinatura
Relativamente à utilização por terceiros a Revista da SPMFR rege-se pelos termos da licença Creative Commons “Atribuição – uso Não-Comercial – Proibição de Realização de Obras derivadas (by-nc-nd)”.
Após publicação na Revista SPMFR, os Autores ficam autorizados a disponibilizar os seus artigos em repositórios das suas instituições de origem, desde que mencionem sempre onde foram publicados.
OS AUTORES DEVERÃO SUBMETER UMA DECLARAÇÃO DE CONTRIBUIÇÃO / CONTRIBUTORSHIP STATEMENT INDICANDO O TIPO DE PARTICIPAÇÃO DE CADA AUTOR NO ARTIGO. Mais informações: https://authors.bmj.com/policies/bmj-policy-on-authorship/
